Morbidity and Mortality Following Short Course Preoperative Radiotherapy in Rectal Carcinoma.

The Effect of Interval From Completion of Short-Course Radiotherapy to Surgery on the Post-Operative Morbidity and Mortality of Patients with Rectal Cancer

Aim Surgery is the mainstay of treatment for invasive rectal cancer. Advances in surgical technique and radiotherapy over the past few decades have resulted in improved local control and survival.1-3 Some concern remains regarding the morbidity associated with performing surgery within a short window following radiotherapy. The current study assessed whether the interval between short-course ra...

Prospective phase II study of preoperative short-course radiotherapy for rectal cancer with twice daily fractions of 2.9 Gy to a total dose of 29 Gy - Long-term results

BACKGROUND To evaluate clinical outcome after preoperative short-course radiotherapy for rectal cancer with twice daily fractions of 2.9 Gy to a total dose of 29 Gy and adjuvant chemotherapy for pathological stage UICC >or= II. METHODS 118 patients (median age 64 years; male : female ratio 2.5 : 1) with pathological proven rectal cancer (clinical stage II 50%, III 41.5%, IV 8.5%) were treated...

Preoperative short-course radiotherapy in locally advanced rectal cancer: the attitude on how to use radiotherapy in rectal cancer is changing.

Preoperative radiotherapy of locally advanced rectal cancer: clinical outcome of short-course and long-course treatment with or without concomitant chemotherapy.

BACKGROUND Preoperative radiotherapy is considered to be standard treatment for locally advanced rectal cancer. The timing and dosage of radiotherapy with or without preoperative chemotherapy remain controversial issues. The objective of this study was to evaluate relevant clinical outcomes of two preoperative radiotherapy regimens - the short-course and -long-course radiotherapy with or withou...

Short-versus Long-course Preoperative Radiotherapy plus Delayed Surgery for Rectal Cancer: a Meta-analysis

Long-course chemo-radiotherapy (45~50 Gy in 25 fractions) with delayed surgery or short-course radiotherapy (25 Gy in 5 fractions) with immediate surgery were the most frequent regimens for the treatment of localized and locally advanced resectable rectal cancer (SWEDISH RECTAL CANCER TRIAL, 1997; Colorectal Cancer Collaborative Group, 2001; Kapiteijn et al., 2001; Sauer et al., 2004). Compared...